3-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline → N-(3-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)prop-2-ynyl)-2-(pyrrolidin-1-yl)acetamide
Reaction equation
[CH2:20]([C:21]#[CH:22])[NH:23][C:24]([CH2:25][N:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1)=[O:31].[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17]([I:19])[s:18]2>>[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17]([C:22]#[C:21][CH2:20][NH:23][C:24]([CH2:25][N:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1)=[O:31])[s:18]2Participants
3
Sources & evidence
- ORD record
- ord-15d82395dd034d0abce541fe31300006
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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