Methyl iodide → 4-(Ethanesulfonyl-methyl-amino)-3-methyl-benzofuran-2-carboxylic acid ethyl ester

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Reaction Steps

4-Ethanesulfonylamino-3-methyl-benzofuran-2-carboxylic acid ethyl ester (prepared according to Example 68, Step 1) was alkylated with iodomethane according to Example 60, Step 2, to give 4-(ethanesulfonyl-methyl-amino)-3-methyl-benzofuran-2-carboxylic acid ethyl ester. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.3 (m, 9 H) 2.7 (s, 3 H) 3.3 (s, 2 H) 4.4 (q, J=7.1 Hz, 2 H) 7.5 (dd, J=7.7, 0.9 Hz, 1 H) 7.6 (m, 1 H) 7.7 (m, 1 H).

Provenance & Evidence