Benzenesulfonyl chloride → 4-Benzenesulfonylamino-3-methyl-benzofuran-2-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2].[C:17]1([S:23](Cl)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][S:23]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:25])=[O:24])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2]Participants
3
Procedure
4-Benzenesulfonylamino-3-methyl-benzofuran-2-carboxylic acid ethyl ester was prepared from 4-amino-3-methyl-benzofuran-2-carboxylic acid ethyl ester (Example 60, Step 1), and benzenesulfonyl chloride according to the procedure of Example 68, Step 1. Yield: 83%. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.3 (t, J=7.2 Hz, 3 H) 2.6 (s, 3 H) 4.4 (q, J=7.1 Hz, 2 H) 6.6 (d, J=7.8 Hz, 1 H) 7.3 (m, 1 H) 7.6 (t, J=7.8 Hz, 3 H) 7.7 (m, 3 H) 10.1 (s, 1 H).
Sources & evidence
- ORD record
- ord-d0610471ce294e20a7a4012088503dd6
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07420001B2
Reaction notes
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