Dimethyl Sulfoxide → Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

HRID 293161Notes

Reaction equation

HRID 293161 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1.[CH3:31][S:32]([CH3:33])=[O:34].[K+:11].[K+:12].[N:17]1([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1.[O-:13][C:14]([O-:15])=[O:16].[OH2:30]>>[c:2]1([N:20]2[CH2:19][CH2:18][N:17]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:22][CH2:21]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 143452tert-Butyl piperazine-1-carboxylateHCID 8176205-Bromo-2-nitropyridine

Product 1

HCID 11243758Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-35354c3ea41b4a7ea816d825afdf90af
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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