HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 5-Ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate | HCID 68711669 | — |
| Product | 5-Ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester | HCID 68714020 | 99.8% |
Reaction Steps
According to the procedure of Example 86, Step 3, 0.250 g (1.01 mmol) of 3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester (Example 86, Step 2) and 0.599 mL (5.04 mmol) of benzyl bromide gave 0.341 g of 5-ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester after chromatography on silica gel eluting with ethyl acetate/hexanes (1:20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07420001B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-c1ba28bdda7f43389a3dc1e9a2fbfd7d |
| Source note | uspto-grants-2008_09 |