Methyl iodide → HCID 68716239, compound

Participants

Reaction Steps

To a solution of 0.077 g (0.14 mmol) of the product of Example 96, Step 2, methyl N-[(4′-{[(3-methyl-4-vinyl-1-benzofuran-2-yl)carbonyl]amino}-1,1′-biphenyl-4-yl)sulfonyl]-L-valinate, in 1 mL of DMF, 0.05 g of potassium carbonate were added, followed by 0.018 mL of iodomethane. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue was extracted with dichloromethane. The organic layer was washed with water and brine, dried over Na2SO4, filtered, and concentrated to provide 0.1 g of methyl N-methyl-N-[(4′-{[(3-methyl-4-vinyl-1-benzofuran-2-yl)carbonyl]amino}-1,1′-biphenyl-4-yl)sulfonyl]-L-valinate. Yield 63.4%. MS: 561 (M+H)+.

Provenance & Evidence