Lithium Hydroxide → 4-Methoxy-3-methylbenzofuran-2-carboxylic acid

Participants

Reaction Steps

To 150 mg of 4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester dissolved in 1 mL of THF was added 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was dried under vacuum to give 120 mg (91% yield) of 4-methoxy-3-methyl-benzofuran-2-carboxylic acid as white solid.

Provenance & Evidence