Ethanol → (2-methyl-1-{2-[5-(4-piperazin-1-yl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-propyl)-carbamic acid methyl ester

HRID 293480Notes

Reaction equation

HRID 293480 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][N:14]([c:17]2[cH:18][cH:19][c:20](-[c:23]3[n:24]([CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:49])([CH3:50])[CH3:51])[c:25]([CH:28]4[N:29]([C:33]([CH:34]([CH:35]([CH3:36])[CH3:37])[NH:38][C:39](=[O:40])[O:41][CH3:42])=[O:43])[CH2:30][CH2:31][CH2:32]4)[n:26][cH:27]3)[cH:21][cH:22]2)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:52][CH2:53][OH:54]>>[NH:11]1[CH2:12][CH2:13][N:14]([c:17]2[cH:18][cH:19][c:20](-[c:23]3[n:24]([CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:49])([CH3:50])[CH3:51])[c:25]([CH:28]4[N:29]([C:33]([CH:34]([CH:35]([CH3:36])[CH3:37])[NH:38][C:39](=[O:40])[O:41][CH3:42])=[O:43])[CH2:30][CH2:31][CH2:32]4)[n:26][cH:27]3)[cH:21][cH:22]2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 702EthanolHCID 666202604-{4-[2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-phenyl]-piperazine-1-carboxylic acid benzyl ester

Product 1

HCID 66620632(2-methyl-1-{2-[5-(4-piperazin-1-yl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-propyl)-carbamic acid methyl ester

Sources & evidence

ORD record
ord-d07445635a894e21a94f0d1c07121d56
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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