HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid methylene chloride → 3-Methyl-4-(3-nitro-phenyl)-benzofuran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Reactant | 3-Methyl-4-(3-nitro-phenyl)-benzofuran-2-carboxylic acid tert-butyl ester | HCID 68715202 | — |
| Product | 3-Methyl-4-(3-nitro-phenyl)-benzofuran-2-carboxylic acid | HCID 68710055 | 92% |
Reaction Steps
To 300 mg of 3-methyl-4-(3-nitro-phenyl)-benzofuran-2-carboxylic acid tert-butyl ester was added 4 mL of TFA/dichloromethane (1:1). The solution was stirred at room temperature for 5 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 232 mg (92% yield) of 3-methyl-4-(3-nitro-phenyl)-benzofuran-2-carboxylic acid as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07420001B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-ab6c9ca0d7e3448f9d3dc917bab48680 |
| Source note | uspto-grants-2008_09 |