1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxy-1,4-dihydro-2H-3,1-benzoxazin-2-one → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-fluoro-3-methylquinazoline-2,4(1H,3H)-dione

HRID 293730Notes

Reaction equation

HRID 293730 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6](=[O:30])[n:7]([CH3:29])[c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1.[NH2:31][CH:32]1[CH2:33][CH2:34][N:35]([CH2:36][CH2:37][N:38]2[c:39]3[cH:40][c:41]([O:42][CH3:43])[cH:44][cH:45][c:46]3[CH2:47][O:48][C:49]2=[O:50])[CH2:51][CH2:52]1>>[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6](=[O:30])[n:7]([CH3:29])[c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]3)[c:10]2[cH:11]1

Participants

3

Reactant 2

HCID 667737621-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxy-1,4-dihydro-2H-3,1-benzoxazin-2-oneHCID 86642639tert-Butyl{1-[2-(7-fluoro-3-methyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667738011-[2-(4-Aminopiperidin-1-yl)ethyl]-7-fluoro-3-methylquinazoline-2,4(1H,3H)-dione

Sources & evidence

ORD record
ord-a594f31c295c47ff9afa4cd5fe05c6db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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