HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid methylene chloride → 3-Methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Reactant | 3-Methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester | HCID 68715453 | — |
| Product | 3-Methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid | HCID 68717306 | 92.8% |
Reaction Steps
To 140 mg 3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester was added 4 mL of TFA/dichloromethane (1:1). The solution was stirred at room temperature for 5 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 107 mg of 3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07420001B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-dcb078251a394645bb7a44e63aa37b69 |
| Source note | uspto-grants-2008_09 |