Diisopropylethylamine → (S)-3-methyl-2-{4'-[(3-methyl-4-morpholin-4-yl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid methyl ester

Participants

Reaction Steps

To 3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid (97 mg, 0.37 mmol) was added (S)-2-(4′-amino-biphenyl-4-sulfonylamino)-3-methyl-butyric acid methyl ester (268 mg, 0.74 mmol), BOP (327 mg, 0.74 mmol), N,N-diisopropylethylamine (0.13 mL, 0.74 mmol) and 4 mL of DMF. The mixture was stirred at room temperature overnight. The reaction mixture was poured into brine, and extracted with ethyl acetate. The combined organic solution was washed with brine and water. Removal of the solvent in vacuo gave the crude product, which was purified by column chromatography on silica gel to give 184 mg of (S)-3-methyl-2-{4′-[(3-methyl-4-morpholin-4-yl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid methyl ester, obtained as an off-white solid.

Provenance & Evidence