Lithium Hydroxide → 5-Chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid

Participants

Reaction Steps

To 105 mg of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of THF and 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was triturated with dichloromethane and dried under vacuum to give 82 mg (87% yield) of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid.

Provenance & Evidence