Lithium Hydroxide → 5,7-Dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid

Participants

Reaction Steps

To 110 mg of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of THF and 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was dried under vacuum to give 96 mg (96% yield) of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid, obtained as a white solid.

Provenance & Evidence