8-(1-piperazinyl)Quinoline → 6-Fluoro-7-[4-(4-quinolin-8-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Reaction equation
[F:1][c:2]1[c:3]([O:13][CH2:14][CH2:15][CH2:16][CH:17]=[O:18])[n:4][c:5]2[c:10]([cH:11]1)[CH2:9][CH2:8][C:7](=[O:12])[NH:6]2.[N:19]1([c:25]2[cH:26][cH:27][cH:28][c:29]3[cH:30][cH:31][cH:32][n:33][c:34]23)[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1>>[F:1][c:2]1[c:3]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][N:22]2[CH2:21][CH2:20][N:19]([c:25]3[cH:26][cH:27][cH:28][c:29]4[cH:30][cH:31][cH:32][n:33][c:34]34)[CH2:24][CH2:23]2)[n:4][c:5]2[c:10]([cH:11]1)[CH2:9][CH2:8][C:7](=[O:12])[NH:6]2Participants
3
Sources & evidence
- ORD record
- ord-87e9d84e51f44caa9ce18e18f95e7886
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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