Trifluoroacetic acid methylene chloride → (S)-3-methyl-2-{4'-[(5-methyl-benzooxazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid

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To (S)-3-methyl-2-{4′-[(5-methyl-benzooxazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid tert-butyl ester (30 mg) was added 2 mL of TFA/CH2Cl2 (1:1). The solution was stirred at room temperature for 3 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 14 mg of (S)-3-methyl-2-{4′-[(5-methyl-benzooxazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.76-0.93 (m, 6 H) 1.84-2.07 (m, 6 H) 3.56 (dd, 1 H) 7.70-7.95 (m, 8 H) 7.98-8.14 (m, 3 H) 11.32-11.41 (m, 1 H).

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