HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29444Generated: October 26, 2026
2-Amino-4-chlorobenzenethiol → Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate
https://huagongshe.com/reaction/29444
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| Reactant | Ethyl 2,2,2-triethoxyacetate | HCID 5090273 | — |
| Product | Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate | HCID 63357893 | — |
Reaction Steps
To 2-amino-4-chloro-benzenethiol (1 g) was added ethyl triethoxyacetate (3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 392 mg of 5-chloro-benzothiazole-2-carboxylic acid ethyl ester as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07420001B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-9c1b852ce64e48d08aabc3d4ddcfefe3 |
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| Source note | uspto-grants-2008_09 |
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