Trifluoroacetic acid methylene chloride → HCID 11330652, compound

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Reaction Steps

To (S)-3-methyl-2-{4′-[(5-trifluoromethyl-benzothiazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid tert-butyl ester (210 mg) was added 3 mL of TFA/CH2Cl2 (1:1). The solution was stirred at room temperature for 3 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 181 mg of (S)-3-methyl-2-{4′-[(5-trifluoromethyl-benzothiazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid as a yellow solid. 1H NMR (400 MHz, DMSO-D6) δ ppm 0.83 (dd, J=12.63, 6.82 Hz, 6 H) 1.92-2.00 (m, 1 H) 3.56 (dd, J=9.35, 6.06 Hz, 1 H) 7.80-7.86 (m, 4 H) 7.88-7.92 (m, 2 H) 7.97 (dd, J=8.59, 1.52 Hz, 1 H) 8.05-8.07 (m, 1 H) 8.09 (d, J=2.78 Hz, 1 H) 8.49 (s, 1 H) 8.57 (d, J=8.59 Hz, 1 H) 11.41 (s, 1 H).

Provenance & Evidence