Dichloromethane → 6,2'-Difluoro-4'-hydroxy-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile

HRID 294524Notes

Reaction equation

HRID 294524 reaction equation
[B:32]([Br:33])([Br:34])[Br:35].[Cl:36][CH2:37][Cl:38].[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:30]#[N:31])[c:7]1-[c:8]1[c:9]([F:29])[cH:10][c:11]([O:27][CH3:28])[c:12](-[c:14]2[cH:15][n:16][c:17]3[n:18]2[n:19][cH:20][c:21]([C:23]([CH3:24])([CH3:25])[OH:26])[n:22]3)[cH:13]1>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:30]#[N:31])[c:7]1-[c:8]1[c:9]([F:29])[cH:10][c:11]([OH:27])[c:12](-[c:14]2[cH:15][n:16][c:17]3[n:18]2[n:19][cH:20][c:21]([C:23]([CH3:24])([CH3:25])[OH:26])[n:22]3)[cH:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 222400846,2'-Difluoro-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]-4'-methoxybiphenyl-2-carbonitrile

Product 1

HCID 1355001016,2'-Difluoro-4'-hydroxy-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile

Sources & evidence

ORD record
ord-e0542bcaf4b1422ab06bfc4649a36b7d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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