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HRID29461

反应详情

EQUATION

反应方程式

HRID 29461 的结构方程式

REACTANTS

反应物

2
结构：COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O
HCID2734650

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

C13H19BO4

结构：BrCc1cc2ccccc2o1
HCID12326316

2-(Bromomethyl)-1-benzofuran

C9H7BrO

PRODUCTS

生成物

1
结构：COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1OCc1cc2ccccc2o1
HCID68713822

未命名化合物

收率 29%

PROCEDURE

实验过程

Alkylation of 2-bromomethyl-benzofuran with 2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol was carried out according to Example 136, Step 3, to give 2-[2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran in 29% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.3 (s, 12 H) 3.9 (s, 3 H) 5.3 (s, 2 H) 6.8 (d, J=0.8 Hz, 1 H) 7.0 (d, J=8.1 Hz, 1 H) 7.2 (m, 1 H) 7.3 (m, 2 H) 7.4 (dd, J=8.0, 1.4 Hz, 1 H) 7.5 (dd, J=8.1, 0.8 Hz, 1 H) 7.5 (dd, J=8.0, 1.1 Hz, 1 H).