4-(3-Methoxy-prop-1-ynyl)-3-methyl-benzofuran-2-carboxylic acid ethyl ester → 4-(3-Methoxy-propyl)-3-methyl-benzofuran-2-carboxylic acid ethyl ester

Participants

Reaction Steps

A mixture of 4-(3-methoxy-prop-1-ynyl)-3-methyl-benzofuran-2-carboxylic acid ethyl ester (2.6566 g, 0.00977 mol, Example 22, Step 1) and 10% palladium on activated carbon (705 mg) and tetrahydrofuran (60 mL) was stirred under a hydrogen atmosphere (balloon) for 20 hours. After filtering the mixture through a celite pad the resulting solution was reduced to dryness furnishing 2.46 g (91%) of of 4-(3-methoxy-propyl)-3-methyl-benzofuran-2-carboxylic acid ethyl ester as a clear oil. MS (ES) m/z: 277.1 (M+H)+, 553.3 (2M+H).

Provenance & Evidence