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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29487Generated: October 28, 2026

1-Ethyl-2-methylbenzimidazole → 1-ethyl-1H-benzimidazole-2-carbaldehyde

https://huagongshe.com/reaction/29487

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-2-methylbenzimidazoleHCID 22054—
ReactantSelenium DioxideHCID 24007—
Product1-ethyl-1H-benzimidazole-2-carbaldehydeHCID 96254452%

Reaction Steps

Oxidation of the 1-ethyl-2-methylbenzimidazole to the corresponding aldehyde using selenium dioxide was conducted according to a literature procedure (Werner et al. Tetrahedron, 1995, 51, 4779). 1-Ethyl-1H-benzimidazole-2-carboxaldehyde was isolated as a yellow oil in overall 52% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420001B2
Source datasetuspto-grants-2008_09
ORD IDord-dd006146bf554c51b3c7df29b9306e8e
Source noteuspto-grants-2008_09