Hydrochloric Acid → Propanamide, N-(4-chlorophenyl)-2,2-dimethyl-

HRID 29502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 29502
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](Cl)(=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 78124-ChloroanilineHCID 62493Pivaloyl chloride

Produkt 1

HCID 182511Propanamide, N-(4-chlorophenyl)-2,2-dimethyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 4-chloroaniline (5.0 g, 39.2 mmol) in 25 mL pyridine was added 5.3 mL (43.1 mmol) of pivaloyl chloride and the reaction mixture stirred overnight at room temperature. The mixture was poured into vigorously stirring 6M HCl, and the solids were collected by vacuum filtration, washed well with H2O, and dried in vacuo to yield the title compound. 1H NMR (CDCl3) δ 7.47 (d, J=9.2 Hz, 2H) 7.30 (s, 1H) 7.27 (d, J=8.8 Hz, 2H) 1.32 (s, 9H) MS (ES) m/z=212.1

Aufarbeitung

  1. additionThe mixture was poured
  2. filtrationthe solids were collected by vacuum filtration
  3. washwashed well with H2O
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-589e425ab02c467ea40f603401976afe
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07420055B2

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