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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 295094Generated: October 26, 2026

tert-Butyl 4-hydroxy-2-(hydroxymethyl)-2,3-dihydrobenzofuran-6-carboxylate → 4-[4-(Azetidine-1-carbonyl)-3-fluoro-phenoxy]-2-hydroxymethyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/295094

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 4-hydroxy-2-(hydroxymethyl)-2,3-dihydrobenzofuran-6-carboxylateHCID 25067321—
ReactantAzetidin-1-yl-(2,4-difluorophenyl)methanoneHCID 59560289—
Reactant6-(4-Methanesulfonyl-phenoxy)-2-methyl-2,3-dihydro-benzofuran-4-carboxylic acid methyl esterHCID 59560437—
Product4-[4-(Azetidine-1-carbonyl)-3-fluoro-phenoxy]-2-hydroxymethyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl esterHCID 59559929—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-773531842f984c3889ecd0f2d2533968
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)