Bicarbonate Ion → N-cyclopentyl-4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

HRID 295173Notes

Reaction equation

HRID 295173 reaction equation
[C:28](=[O:29])([O-:30])[OH:31].[CH2:1]([CH3:2])[c:3]1[s:4][c:5](-[c:15]2[cH:16][c:17]([F:21])[n:18][cH:19][cH:20]2)[c:6](-[c:8]2[cH:9][c:10]([CH3:14])[cH:11][cH:12][cH:13]2)[n:7]1.[CH:22]1([NH2:27])[CH2:23][CH2:24][CH2:25][CH2:26]1.[Na+:32]>>[CH2:1]([CH3:2])[c:3]1[s:4][c:5](-[c:15]2[cH:16][c:17]([NH:27][CH:22]3[CH2:23][CH2:24][CH2:25][CH2:26]3)[n:18][cH:19][cH:20]2)[c:6](-[c:8]2[cH:9][c:10]([CH3:14])[cH:11][cH:12][cH:13]2)[n:7]1

Participants

5

Reactant 4

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 2906CyclopentylamineHCID 99008852-Ethyl-5-(2-fluoro-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazole

Product 1

HCID 9947156N-cyclopentyl-4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Sources & evidence

ORD record
ord-fdfa1ee17c00446a939c2ba7e5c8f535
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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