反应详情

温度

70 °C

5-Phenyloxazole (2.0 g, mmol) in chloroform (50 ml) was cooled to 0° C. using an ice bath. Chlorosulfonic acid 4.8 g (2.7 ml, 3 eq) of was added slowly with stirring. The reaction mixture was heated to 70° C. for 16 h. The reaction mixture was then cooled to RT, quenched with ice and extracted with chloroform. The organic layer was washed with cold water, brine and concentrated. The brown solid obtained was purified by column chromatography using 5% ethyl acetate in pet ether as eluent, to yield a yellow solid.

1. temperatureThe reaction mixture was then cooled to RT
2. customquenched with ice
3. extractionextracted with chloroform
4. washThe organic layer was washed with cold water, brine
5. concentrationconcentrated
6. customThe brown solid obtained
7. customwas purified by column chromatography
8. customto yield a yellow solid