Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29551Generated: October 27, 2026

4-Methoxybenzenesulfonyl chloride → N-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-methoxy-benzenesulfonamide

https://huagongshe.com/reaction/29551

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzenesulfonyl chlorideHCID 7401—
Reactant(2-Amino-5-bromophenyl)(pyridin-4-yl)methanoneHCID 13549724—
ProductN-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-methoxy-benzenesulfonamideHCID 10049261—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 138 mg of (2-amino-5-bromo-phenyl)-pyridin-4-yl-methanone and 101 mg of 4-methoxy-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 3.69 (s, 3H), 6.68 (d, 2H, J=8.8 Hz), 7.36-7.47 (m, 4H), 7.46, 7.55-7.69 (m, 5H), 9.65 (s, 1H). MS: m/z 448.3 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-7b727e2eaf4a47c7b660c56ae8e3f795
Source noteuspto-grants-2008_09