1-[(5-Bromo-2-thienyl)carbonyl]pyrrolidine → [2-Fluoro-4-[5-(pyrrolidine-1-carbonyl)thiophen-2-yl]phenyl]-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidin-1-yl]methanone

HRID 295624Notes

Reaction equation

HRID 295624 reaction equation
[Br:31][c:32]1[cH:33][cH:34][c:35]([C:37](=[O:38])[N:39]2[CH2:40][CH2:41][CH2:42][CH2:43]2)[s:36]1.[F:1][c:2]1[c:3]([C:17](=[O:18])[N:19]2[CH:20]([CH2:24][N:25]3[CH:26]([CH3:30])[CH2:27][CH2:28][CH2:29]3)[CH2:21][CH2:22][CH2:23]2)[cH:4][cH:5][c:6]([B:8]2[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]2)[cH:7]1>>[F:1][c:2]1[c:3]([C:17](=[O:18])[N:19]2[CH:20]([CH2:24][N:25]3[CH:26]([CH3:30])[CH2:27][CH2:28][CH2:29]3)[CH2:21][CH2:22][CH2:23]2)[cH:4][cH:5][c:6](-[c:32]2[cH:33][cH:34][c:35]([C:37](=[O:38])[N:39]3[CH2:40][CH2:41][CH2:42][CH2:43]3)[s:36]2)[cH:7]1

Participants

3

Reactant 2

HCID 12465611-[(5-Bromo-2-thienyl)carbonyl]pyrrolidineHCID 76694943[2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidin-1-yl]methanone

Product 1

HCID 11655757[2-Fluoro-4-[5-(pyrrolidine-1-carbonyl)thiophen-2-yl]phenyl]-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidin-1-yl]methanone

Sources & evidence

ORD record
ord-eabbce909ad640c99bd930a6564e7465
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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