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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29564Generated: October 26, 2026

4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → N-[4-Chloro-2-(6-methyl-pyridine-3-carbonyl)-phenyl]-4-oxazol-5-yl-benzenesulfonamide

https://huagongshe.com/reaction/29564

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(1,3-Oxazol-5-yl)benzenesulphonyl chlorideHCID 2776415—
Reactant(2-Amino-5-chloro-phenyl)-(6-methyl-pyridin-3-yl)methanoneHCID 22327305—
ProductN-[4-Chloro-2-(6-methyl-pyridine-3-carbonyl)-phenyl]-4-oxazol-5-yl-benzenesulfonamideHCID 10389230—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 123 mg of (2-Amino-5-chloro-phenyl)-(6-methyl-pyridin-3-yl)-methanone and 122 mg of 4-oxazol-5-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 2.63 (s, 3H), 7.33 (m, 2H), 7.37 (s, 1H), 7.56 (m, 3H), 7.67-7.3 (m, 3H), 7.94 (m, 1H), 7.97 (s, 1H), 8.52 (b, 1H), 9.45 (s, 1H). MS: m/z 454.1 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-178177b8b0234d5cae67d843198547f6
Source noteuspto-grants-2008_09