Ethyl 5-(4-(difluoromethoxy)phenyl)-1,3,4-oxadiazole-2-carboxylate → (5-(4-(Difluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)(3-(4-((dimethylamino)methyl)phenoxy)azetidin-1-yl)methanone

HRID 295697Notes

Reaction equation

HRID 295697 reaction equation
[F:16][CH:17]([O:18][c:19]1[cH:20][cH:21][c:22](-[c:25]2[n:26][n:27][c:28]([C:30](=[O:31])[O:32][CH2:33][CH3:34])[o:29]2)[cH:23][cH:24]1)[F:35].[NH:1]1[CH2:2][CH:3]([O:5][c:6]2[cH:7][cH:8][c:9]([CH2:12][N:13]([CH3:14])[CH3:15])[cH:10][cH:11]2)[CH2:4]1>>[N:1]1([C:30]([c:28]2[n:27][n:26][c:25](-[c:22]3[cH:21][cH:20][c:19]([O:18][CH:17]([F:16])[F:35])[cH:24][cH:23]3)[o:29]2)=[O:31])[CH2:2][CH:3]([O:5][c:6]2[cH:7][cH:8][c:9]([CH2:12][N:13]([CH3:14])[CH3:15])[cH:10][cH:11]2)[CH2:4]1

Participants

3

Reactant 2

HCID 58043152Ethyl 5-(4-(difluoromethoxy)phenyl)-1,3,4-oxadiazole-2-carboxylateHCID 666531201-(4-(Azetidin-3-yloxy)phenyl)-N,N-dimethylmethanamine

Product 1

HCID 56598129(5-(4-(Difluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)(3-(4-((dimethylamino)methyl)phenoxy)azetidin-1-yl)methanone

Sources & evidence

ORD record
ord-b8071439f5de4d518870c263ac9c52e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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