Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29570Generated: October 26, 2026

4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → N-[4-Chloro-2-(pyridine-3-carbonyl)-phenyl]4-oxazol-5-yl-benzenesulfonamide

https://huagongshe.com/reaction/29570

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(1,3-Oxazol-5-yl)benzenesulphonyl chlorideHCID 2776415—
Reactant(2-Amino-5-chlorophenyl)(pyridin-3-yl)methanoneHCID 13549723—
ProductN-[4-Chloro-2-(pyridine-3-carbonyl)-phenyl]4-oxazol-5-yl-benzenesulfonamideHCID 10003341—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-pyridin-3-yl-methanone and 122 mg of 4-oxazol-5-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 7.23 (m, 2H), 7.42-7.47 (m, 3H), 7.58-7.62 (m, 3H), 7.71 (dt, 1H, J=7.6 Hz, 2.0 Hz), 7.88 (s,1H), 8.45 (b,1H), 8.58 (bd,1H, J=3.6 Hz), 9.67 (s,1H). MS: m/z 458.1 (M++1)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-df37cad39ce04b818dd855d796692345
Source noteuspto-grants-2008_09