Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29577Generated: October 29, 2026

4-t-Butylbenzenesulfonyl chloride → 4-tert-Butyl-N-[3,4-difluoro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide

https://huagongshe.com/reaction/29577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-t-Butylbenzenesulfonyl chlorideHCID 139882—
ReactantHCID 22327303HCID 22327303—
Product4-tert-Butyl-N-[3,4-difluoro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamideHCID 10455361—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 117 mg of (6-Amino-2,3-difluoro-phenyl)-pyridin-4-yl-methanone and 116 mg of 4-tert-Butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.22 (s, 9H), 7.31 (d, 2H, J=8.4 Hz), 7.40-7.47 (m, 3H), 7.55 (d, 2H, J=8.4 Hz), 7.59 (m,1H), 8.69 (b,1H), 8.82 (d, 2H, J=6.0 Hz). MS: m/z 431.0 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-82495643fec74c5ea23224ced44663fa
Source noteuspto-grants-2008_09