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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29579Generated: October 29, 2026

(2-Amino-5-chlorophenyl)-pyridin-4-yl methanone → N-(4-Chloro-2-isonicotinoylphenyl)-4-isopropoxybenzenesulfonamide

https://huagongshe.com/reaction/29579

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Amino-5-chlorophenyl)-pyridin-4-yl methanoneHCID 10214538—
Reactant4-(Propan-2-yloxy)benzene-1-sulfonyl chlorideHCID 22327297—
ProductN-(4-Chloro-2-isonicotinoylphenyl)-4-isopropoxybenzenesulfonamideHCID 10432875—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 117 mg of 4-Isopropoxy-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.01 (d, 6H, J=5.6 Hz), 4.27 (m, 1H), 6.51 (d, 2H, J=8.8 Hz), 6.87 (d, 1H, J=8.8 Hz), 7.15-7.25 (m, 4H), 7.60 (d, 2H, J=6.0 Hz), 8.64 (d, 2H, J=6 Hz), 9.60 (s, 1H). MS: m/z 431.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-dc4c531eaa6d4fd89958f1694ed4097d
Source noteuspto-grants-2008_09