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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29587Generated: October 27, 2026

p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide

https://huagongshe.com/reaction/29587

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Trifluoromethoxy)benzenesulphonyl chlorideHCID 523102—
Reactant(2-Amino-5-chlorophenyl)-pyridin-4-yl methanoneHCID 10214538—
ProductN-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamideHCID 10095610—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 4-Trifluoromethoxy-benzenesulfonyl chloride and purified by HPLC. 1H NMR (DMSO-d6): δ 6.90 (d, J=8.4 Hz, 1H), 7.50 (d, J=8.8 Hz, 2H), 7.49-7.61 (m, 4H), 7.66 (d, J=8.8 Hz, 2H), 8.81 (d, J=4.8 Hz, 2H), 10.26 (s, 1H). MS: M/z 456.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-e3d81c7ce0da44458092b7aa5eb92849
Source noteuspto-grants-2008_09