(2-Amino-5-chloro-phenyl)-(6-methyl-pyridin-2-yl)-methanone → N-[4-Chloro-2-(6-methyl-pyridine-2-carbonyl)-phenyl]-4-(2-methyl-oxazol-5-yl)-benzenesulfonamide

HRID 29614Notes

Reaction equation

HRID 29614 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:5][N:6]=1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH3:33])[N:28]=1)=[O:26]>>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([NH:17][S:13]([C:10]2[CH:11]=[CH:12][C:7]([C:4]3[O:3][C:2]([CH3:1])=[N:6][CH:5]=3)=[CH:8][CH:9]=2)(=[O:15])=[O:14])=[C:19]([C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([CH3:33])[N:28]=2)=[O:26])[CH:20]=1

Participants

3

Reactant 2

HCID 22327312(2-Amino-5-chloro-phenyl)-(6-methyl-pyridin-2-yl)-methanoneHCID 529970604-(2-Methyl-1,3-oxazol-5-yl)benzenesulfonyl chloride

Product 1

HCID 20827699N-[4-Chloro-2-(6-methyl-pyridine-2-carbonyl)-phenyl]-4-(2-methyl-oxazol-5-yl)-benzenesulfonamide

Procedure

The title compound was prepared according to the general procedure for the preparation of N-aryl-benzenesulfonamides using 4-(2-methyl-oxazol-5-yl)-benzenesulfonyl chloride and (2-Amino-5-chloro-phenyl)-(6-methyl-pyridin-2-yl)-methanone and purified by HPLC. MS: m/z 468.0 (M++1).

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-665e6f0b459f4cd4a21199a12668d04e
Source dataset
uspto-grants-2008_09
Patent number
US07420055B2

Reaction notes

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