Water → 2,6-Dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-(2-[4-(2-acetoxyethyl)phenoxy]ethoxycarbonyl)-1,4-dihydropyridine

HRID 296332Notes

Reaction equation

HRID 296332 reaction equation
[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH3:11])[CH:6]([c:12]2[cH:13][c:14]([N+:18](=[O:19])[O-:20])[cH:15][cH:16][cH:17]2)[C:5]([C:21](=[O:22])[O:23][CH2:24][CH2:25][O:26][c:27]2[cH:28][cH:29][c:30]([CH2:33][CH2:34][OH:35])[cH:31][cH:32]2)=[C:4]([CH3:36])[NH:3]1.[CH3:43][C:44](=[O:45])[O:46][C:47](=[O:48])[CH3:49].[Cl:51][CH2:52][Cl:53].[OH2:50].[cH:37]1[cH:38][cH:39][n:40][cH:41][cH:42]1>>[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH3:11])[CH:6]([c:12]2[cH:13][c:14]([N+:18](=[O:19])[O-:20])[cH:15][cH:16][cH:17]2)[C:5]([C:21](=[O:22])[O:23][CH2:24][CH2:25][O:26][c:27]2[cH:28][cH:29][c:30]([CH2:33][CH2:34][O:35][C:44]([CH3:43])=[O:45])[cH:31][cH:32]2)=[C:4]([CH3:36])[NH:3]1

Participants

6

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 142087992,6-Dimethyl-3-carbomethoxy-4-(3-nitrophenyl)-5-(2-[4-(2-hydroxyethyl)phenoxy]ethoxycarbonyl)-1,4-dihydropyridine

Product 1

HCID 142088002,6-Dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-(2-[4-(2-acetoxyethyl)phenoxy]ethoxycarbonyl)-1,4-dihydropyridine

Sources & evidence

ORD record
ord-8dc4ee3fdff940bc9ff53aac700e0129
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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