5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{3-[4-(5-Chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-pyridin-2-ylamine

HRID 296420Notes

Reaction equation

HRID 296420 reaction equation
[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:20]([F:21])([F:22])[F:23])[cH:11][c:12](-[c:14]3[s:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:13]2)[cH:5][cH:6][cH:7]1.[NH2:24][c:25]1[n:26][cH:27][c:28]([B:31]2[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]2)[cH:29][cH:30]1>>[c:2]1(-[c:28]2[cH:27][n:26][c:25]([NH2:24])[cH:30][cH:29]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([C:20]([F:21])([F:22])[F:23])[cH:11][c:12](-[c:14]3[s:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:13]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 673946642-(3-Bromo-phenyl)-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 250969425-{3-[4-(5-Chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-pyridin-2-ylamine

Sources & evidence

ORD record
ord-268510b826cf41bc851a95991143e2bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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