HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 2-Mercapto-3-isopropylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Reactant | Benzenethiol, 2-(1-methylethyl)- | HCID 96003 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Product | 2-Mercapto-3-isopropylbenzoic acid | HCID 10655507 | — |
Reaction Steps
To a solution of 1.0 mmol 2-isopropylthiophenol and 2.2 mmol TMEDA in 2 mL cyclohexane was added 2.2 mmol n-BuLi. Then after stirring 24 h it was added to solid CO2 and stirred for 16 h when extraction and chromatography provided 2-mercapto-3-isopropylbenzoic acid. The methyl ester of this was treated as in example 3 to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731432 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-8bfebd9748154a9780039335f8d6e481 |
| Source note | uspto-grants-1998_03 |