Bicarbonate Ion → 2-(1-ethoxymethyl-1H-imidazol-2-yl)-thiazole

HRID 296662Notes

Reaction equation

HRID 296662 reaction equation
[Br:23][c:24]1[s:25][cH:26][cH:27][n:28]1.[CH2:1]([CH3:2])[O:3][CH2:4][n:5]1[c:6]([Sn:10]([CH2:11][CH2:12][CH2:13][CH3:14])([CH2:15][CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH2:21][CH3:22])[n:7][cH:8][cH:9]1.[CH3:58][c:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1.[F:29][c:30]1[cH:31][c:32](-[c:33]2[n:34]([CH2:35][CH:36]3[NH:37][c:38]4[cH:39][n:40][cH:41][cH:42][c:43]4[N:44]3[CH2:45][CH3:46])[cH:47][cH:48][n:49]2)[cH:50][cH:51][cH:52]1.[Na+:57].[O-:53][C:54]([OH:55])=[O:56]>>[CH2:1]([CH3:2])[O:3][CH2:4][n:5]1[c:6](-[c:24]2[s:25][cH:26][cH:27][n:28]2)[n:7][cH:8][cH:9]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 1140TolueneHCID 764302-BromothiazoleHCID 222603931-ethoxymethyl-2-tributylstannanyl-1H-imidazoleHCID 223801792-{[2-(3-Fluorophenyl)-1H-imidazol-1-yl]methyl}-1-ethyl-3H-imidazo[4,5-c]pyridine

Product 1

HCID 222603972-(1-ethoxymethyl-1H-imidazol-2-yl)-thiazole

Sources & evidence

ORD record
ord-7d7ae9c373a746a8b68d97388e825842
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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