HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → N-formylphenylalanine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-formylphenylalanine methyl ester | HCID 7016392 | — |
Reaction Steps
To a mixture of 1 mmol of phenylalanine methyl ester hydrochloride and 2 mmol of triethylamine in 1 mL of DMF at 0 ° C. was added 2 mL of formic acid and 0.7 mL of acetic anhydride. After stirring for 16 h at rt, extractive isolation provided N-formylphenylalanine methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731432 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-2f2ad81b1f6b433ea7c984999ad32978 |
| Source note | uspto-grants-1998_03 |