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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 296848Generated: October 26, 2026

4-(4-Hydroxyphenyl)thiophene-3-carbonitrile → (E)-methyl 5-(5-(4-cyanothiophen-3-yl)-2-hydroxybenzyl)-2-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate

https://huagongshe.com/reaction/296848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Hydroxyphenyl)thiophene-3-carbonitrileHCID 59447572—
Reactantethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylateHCID 59447596—
Reactant(E)-methyl 5-(hydroxymethyl)-2-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylateHCID 59447664—
Reactanttert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylateHCID 136027725—
Product(E)-methyl 5-(5-(4-cyanothiophen-3-yl)-2-hydroxybenzyl)-2-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylateHCID 59447680—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-64f098262752407489d997f9fa980288
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)