1-(4-Chloro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester → 1-(4-Chloro-benzoyl)-3-[5-(4-chloro-phenyl)-pyrazin-2-yloxymethyl]-pyrrolidine-3-carboxylic acid ethyl ester

HRID 297033Notes

Reaction equation

HRID 297033 reaction equation
[CH2:15]([CH3:16])[O:17][C:18](=[O:19])[C:20]1([CH2:34][I:35])[CH2:21][N:22]([C:25]([c:26]2[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]2)=[O:33])[CH2:23][CH2:24]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][c:11]([OH:14])[n:12][cH:13]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][c:11]([O:14][CH2:34][C:20]3([C:18]([O:17][CH2:15][CH3:16])=[O:19])[CH2:21][N:22]([C:25]([c:26]4[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]4)=[O:33])[CH2:23][CH2:24]3)[n:12][cH:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 593221801-(4-Chloro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl esterHCID 178516753HCID 178516753, compound

Product 1

HCID 593221661-(4-Chloro-benzoyl)-3-[5-(4-chloro-phenyl)-pyrazin-2-yloxymethyl]-pyrrolidine-3-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-6a6c45267b434573bf1579553b190086
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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