HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Methyl 5-amino-2-hydroxypentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-Tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester | HCID 54330025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 5-amino-2-hydroxypentanoate | HCID 54185808 | — |
Reaction Steps
TFA (2 mL) was added to a solution of 5-tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester in methylene chloride (10 mL) and the mixture was stirred for 3 h and then concentrated under reduced pressure to give crude 5-amino-2-hydroxy-pentanoic acid methyl ester (1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423012B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-4ce8f4f97441444686cbcd0b3321a77e |
| Source note | uspto-grants-2008_09 |