HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2975Generated: October 25, 2026
Methanol → Methyl 3-carbomethoxy-4-fluorobenzaldehyde
https://huagongshe.com/reaction/2975
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | Methyl 3-carbomethoxy-4-fluorobenzaldehyde | HCID 19688468 | — |
Reaction Steps
A mixture of 1.0 mmol of 3-bromo-4-fluorobenzaldehyde, 4 mL of DMF, 0.2 mL of triethylamine, 0.4 mL of MeOH and 0.05 mmol of Pd(PPh3)4 was heated at 90° C. at 40 psi under CO atmosphere for 16 h. Extraction and chromatography provided methyl 3-carbomethoxy-4-fluorobenzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05731432 |
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| Source dataset | uspto-grants-1998_03 |
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| ORD ID | ord-d9642a5bf49d4ae5ab36a31093ec85a4 |
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| Source note | uspto-grants-1998_03 |
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