反应详情

Periodinane (26.9 g, 63.5 mmol) was added to 4-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (10.5 g, 48.8 mmol) in CH2Cl2 (200 mL) and stirred for 90 min. Diethyl ether (560 mL) was added and precipitates were removed by extraction with 10% Na2S2O3/saturated NaHCO3 (1:1, 300 mL). The organic layer was washed with 0.5 M NaOH solution and brine. The organic phase was dried and concentrated under reduced pressure. Purification using flash chromatography (hexane/EtOAc, 8:2) gave 4-Formyl-piperidine-1-carboxylic acid tert-butyl ester (8.5 g, 81%).

1. customprecipitates
2. customwere removed by extraction with 10% Na2S2O3/saturated NaHCO3 (1:1, 300 mL)
3. washThe organic layer was washed with 0.5 M NaOH solution and brine
4. customThe organic phase was dried
5. concentrationconcentrated under reduced pressure
6. customPurification