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Acetic Acid → HCID 178453946、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | rac-tert-butyl N-[(1r,4r)-4-formylcyclohexyl]carbamate | HCID 11020615 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178453946 | HCID 178453946 | 97% |
反応手順
A mixture of (4-Formyl-cyclohexyl)-carbamic acid tert-butyl ester (3.80 g, 16.7 mmol), benzylamine (1.82 g, 16.7 mmol), acetic acid (0.01 g, 16.7 mmol) and anhydrous magnesium sulfate (4.01 g, 33.3 mmol) in methylene chloride (20 mL) was stirred for 5 days. The mixture was filtered through Celite and concentrated under reduced pressure to give trans-[4-(benzylimino-methyl)-cyclohexyl]-carbamic acid tert-butyl ester (5.10 g, 97%) as a 97:3 trans:cis mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423012B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-67c0726d081f47c497c6dc117ec935da |
| 出典メモ | uspto-grants-2008_09 |