HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 66886112, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(3,5-Difluoro-phenyl)-5-methyl-[1,2,4]triazole | HCID 43166806 | — |
| Reactant | tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate | HCID 57429079 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | HCID 66886112 | HCID 66886112 | — |
Reaction Steps
3.74 g (19 mmol) 3-(3,5-difluoro-phenyl)-5-methyl-[1,2,4]triazole in 25 mL DMPU are reacted with 0.92 g (23 mmol, 60%) sodium hydride, 6.37 g (29 mmol) tert-butyl (3-chloro-1,1-dimethyl-propyl)-carbamate and 1.27 g (3.5 mmol) tetrabutylammonium iodide analogously to intermediate product 1c). Oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423036B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-1798b943cf5c4f93a6535bbb920c5aa5 |
| Source note | uspto-grants-2008_09 |