HCID 178465662, compound → 3-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole

HRID 29808Notes

Reaction equation

HRID 29808 reaction equation
[NH:1]=[C:2]([NH:4][NH:5][C:6](=O)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)[CH3:3]>C(Cl)(Cl)Cl>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]2[N:1]=[C:2]([CH3:3])[NH:4][N:5]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 178465662HCID 178465662, compound

Product 1

HCID 124680223-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazoleYield 21.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

6.10 g (28.8 mmol) 4-chloro-benzoic acid N′-(1-imino-ethyl)-hydrazide are heated to 180° C. for 30 minutes. After cooling 2.3 g product are obtained from the residue by recrystallisation in chloroform. Evaporation of the mother liquor and subsequent purification of the residue by chromatography (silica gel, petroleum ether/ethyl acetate=1:6) yield an additional 1.22 g of product. White solid.

Workup

  1. customEvaporation of the mother liquor and subsequent purification of the residue by chromatography (silica gel, petroleum ether/ethyl acetate=1:6)

Sources & evidence

ORD record
ord-7509f253ea474a3589f9f816440e0d0f
Source dataset
uspto-grants-2008_09
Patent number
US07423036B2

Reaction notes

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