Toluene → 2,2'-Difluorobenzophenone

HRID 298148Notes

Reaction equation

HRID 298148 reaction equation
[C:11](=[O:12])([O-:13])[O-:14].[CH3:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[Cs+:15].[Cs+:16].[F:17][c:18]1[c:19]([C:20](=[O:21])[Cl:22])[cH:23][cH:24][cH:25][cH:26]1.[F:1][c:2]1[c:3]([B:8]([OH:9])[OH:10])[cH:4][cH:5][cH:6][cH:7]1.[cH:34]1[cH:35][cH:36][c:37]([P:38]([Pd:39]([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[P:78]([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[cH:109][cH:110]1>>[F:1][c:2]1[c:3]([C:20]([c:19]2[c:18]([F:17])[cH:26][cH:25][cH:24][cH:23]2)=[O:21])[cH:4][cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 1140TolueneHCID 98082-Fluorobenzoyl chlorideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27343542-Fluorophenylboronic acidHCID 178420554HCID 178420554, compound

Product 1

HCID 676492,2'-Difluorobenzophenone

Sources & evidence

ORD record
ord-2c0373d6656943599c1f9f2338d3a9cc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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