Hydrochloric Acid → 7-Acetyl-5-(benzyloxy)-1,3-benzoxazol-2(3H)-one

Participants

Reaction Conditions

Reaction Steps

52 g (0.53 mol) phosgene are piped into a solution of 121 g (0.47 mol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 800 mL pyridine at 20 to 40° C. The reaction mixture is heated to 50° C. for 2 hours, then poured onto ice and acidified with conc. hydrochloric acid. A reddish-brown solid is isolated which is repeatedly recrystallised from ethanol with the addition of activated charcoal.

Provenance & Evidence